Oxidación y antioxidantes: hechos y controversias

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Artículo de revisión
Rev Asoc Colomb Dermatol. 2016; 24: 3 (Julio-Septiembre), 162-173

Oxidación y antioxidantes: hechos y controversias

Oxidation and antioxidants: facts and controversies
Claudia Juliana Mariaca
Médica dermatóloga, Universidad Pontificia Bolivariana, Medellín, Colombia.
Mónica Zapata
Médica dermatóloga, Universidad CES, Medellín, Colombia.
Paulina Uribe
Médica dermatóloga; docente de Dermatología, Universidad Pontificia Bolivariana, Medellín, Colombia.

El envejecimiento se caracteriza por cambios progresivos en los tejidos que dan lugar a la disminución de la función y, finalmente, a la muerte. A lo largo de los años se han descrito múltiples teorías tratando de explicar por qué se produce el envejecimiento. Una de las más aceptadas es la teoría de los radicales libres, la cual sugiere que las especies reactivas del oxígeno forman productos endógenos al reaccionar con otras moléculas, y que estas juegan un papel importante en el envejecimiento. Las células y los órganos del cuerpo tienen sistemas antioxidantes, los cuales pueden ser enzimáticos, no enzimáticos o proteínas de unión. Todos actúan sinérgicamente para neutralizar las diferentes especies reactivas del oxígeno, formando una red de antioxidantes que retrasan el proceso de envejecimiento.

Palabras clave: 
radicales libres, envejecimiento, antioxidantes, piel.


Aging is characterized by progressive changes in the tissues that give place to a decrease in their function and finally death. Over the years, many theories have tried to explain why aging is produced. One of the most accepted is the theory of free radicals that suggests that reactive oxygen species produce endogenous products when they react with other molecules, playing an important role in the aging process.

Key words: 
Free radicals, aging, antioxidants, skin.
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Oxidación y antioxidantes
Oxidación y antioxidantes


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