Artículo científico de dermatología sobre la estructura de la piel pdf

Volumen 21 Número 2 Abril-Junio 2013

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Artículo de revisión

Rev Asoc Colomb Dermatol. 2013; 21: 2 (Abril-Junio), 147-158

Microbiota de la piel: el ecosistema cutáneo

Skin microbiota: The cutaneous ecosystem

Autor(es):

Luz Angélica Patiño

camiderm@yahoo.com

Médica, residente de segundo año de Dermatología, Facultad de Medicina, Universidad CES, Medellín, Colombia; Centro Dermatológico Federico Lleras Acosta, E.S.E., Bogotá, D.C., Colombia

Camilo Andrés Morales

Médico dermatólogo, Oficina de Docencia e Investigación, Centro Dermatológico Federico Lleras Acosta, E.S.E., Bogotá, D.C., Colombia; instructor, Facultad de Medicina, Universidad CES, Medellín, Colombia.

Resumen:

En la superficie cutánea cohabitan bacterias, hongos y parásitos que, en condiciones normales, constituyen un complejo ecosistema en permanente interacción con el huésped. Este ecosistema participa activamente en la doble función protectora de la piel, como barrera física e inmunológica. Por lo tanto, cuando el equilibrio del ecosistema se trastorna, se generan consecuencias negativas que predisponen y causan la aparición de enfermedades. En esta revisión se describen las características del ecosistema cutáneo, la composición de la microbiota de la piel, su variabilidad y las bases fisiológicas de sus principales interacciones.

Palabras clave:

microbiota, ecosistema, microbiología, flora cutánea.

Summary:

In the skin surface cohabite bacteria, fungi and parasites; these microbes constitute a complex ecosystem which is in constant interaction with the host. This ecosystem is actively involved in the double protective function of the skin, as a physical and immunological barrier. When the balance of the ecosystem is disturbed, it has negative consequences and predisposes to disease. In this review, we describe the characteristics of the ecosystem of the skin, the skin micriobiota composition, its variability and the physiological basis of their main interactions.

Key words:

microbiota, ecosystem, microbiology, skin flora

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Gallo RL, Nakatsuji T. Microbial symbiosis with the innate immune defense system of the skin. J Invest Dermatol. 2011;131:1974-80.
Navarro FA. Glosario dermatológico de dudas inglés-español (1ª parte): A-F. Actas Dermosifiliogr. 1999;90:327-38.
Prats G. Los microbios y la enfermedad. En: Prats G. Microbiología clínica. Primera edición. Madrid: Editorial Médica Panamericana; 2006. p. 1-14
Kong HH, Segre JA. Skin microbiome: Looking back to move forward. J Invest Dermatol. 2012;13:933-9.
Kligman AM, Leyden JJ, McGinley KJ. Bacteriology. J Invest Dermatol. 1976;67:160-8.
Marples MJ. Life on the human skin. Sci Am. 1969;220:108-15.
Fredricks DN. Microbial ecology of human skin in health and disease. J Invest Dermatol Symp Proc. 2001;6:167-9.
Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011;9:244-53.
Zhao L. Genomics: The tale of our other genome. Nature. 2010;465:879-80.
Kong HH. Skin microbiome: Genomics-based insights into the diversity and role of skin microbes. Trends Mol Med. 2011;17:320-8.
Cogen AL, Nizet V, Gallo RL. Skin microbiota: A source of disease or defence? Br J Dermatol. 2008;158:442-55.
Verhulst NO, Qiu YT, Beijleveld H, Maliepaard C, Knights D, Schulz S. Composition of human skin microbiota affects attractiveness to malaria mosquitoes. PLoS One. 2011;6:e28991.
De Jong R, Knols BG. Selection of biting sites on man by two malaria mosquito species. Experientia. 1995;51:80-4.
Roth RR, James WD. Microbiology of the skin: Resident flora, ecology, infection. J Am Acad Dermatol. 1989;20:367-90.
Reid G, Younes JA, van der Mei HC, Gloor GB, Knight R, Busscher HJ. Microbiota restoration: Natural and supplemented recovery of human microbial communities. Nat Rev Microbiol. 2011;9:27-38.
Hoffjan S, Stemmler S. On the role of the epidermal differentiation complex in ichthyosis vulgaris, atopic dermatitis and psoriasis. Br J Dermatol. 2007;157:441-9.
Gambichler T, Boms S, Stucker M, Kreuter A, Moussa G, Sand M, et al. Epidermal thickness assessed by optical coherence tomography and routine histology: Preliminary results of method comparison. J Eur Acad Dermatol Venereol. 2006;20:791-5.
Mourelatos K, Eady EA, Cunliffe WJ, Clark SM, Cove JH. Temporal changes in sebum excretion and propionibacterial colonization in preadolescent children with and without acne. Br J Dermatol. 2007;156:22-31.
Pessanha B, Farb A, Lwin T, Lloyd B, Virmani R. Infectious endocarditis due to Corynebacterium xerosis. Cardiovasc Pathol. 2003;12:98-101.
Bierbaum G, Götz F, Peschel A, Kupke T, van de Kamp M, Sahl HG. The biosynthesis of the lantibiotics epidermin, gallidermin, Pep5 and epilancin K7. Antonie van Leeuwenhoek.1996;69:119-27.
Wächtler B, Citiulo F, Jablonowski N, Förster S, Dalle F, Schaller M, et al. Candida albicans-epithelial interactions: Dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PLoS One. 2012;7:e36952.
Waggoner-Fountain LA, Walker MW, Hollis RJ, Pfaller MA, Ferguson JE 2nd, Wenzel RP, et al. Vertical and horizontal transmission of unique Candida species to premature newborns. Clin Infect Dis. 1996;22:803-8.
Ashbee HR. Update on the genus Malassezia. Med Mycol. 2007;45:287-303.
Prohic A, Kasumagic-Halilovic E. Identification of Malassezia pachydermatis from healthy and diseased human skin. Med Arh. 2009,63:317-9.
Hernández FH, Javier L, Tovar M, Mora EB, López AA. Especies de Malassezia asociadas a diversas dermatosis y a piel sana en población mexicana. Rev Iberoam Micol. 2003;52:141-4.
Gaitanis G, Chasapi V, Velegraki A. Novel application of the masson-fontana stain for demonstrating Malassezia species melanin-like pigment production in vitro and in clinical specimens. J Clin Microbiol. 2005;43:4147-51.
Akaza N, Akamatsu H, Sasaki Y, Takeoka S, Kishi M, Mizutani H, et al. Cutaneous Malassezia microbiota of healthy subjects differ by sex, body part and season. J Dermatol. 2010;7:786-92.
Chagas-Neto TC, Chaves GM, Colombo AL. Update on the genusTrichosporon. Mycopathologia. 2008;166:121-32.
Biasoli MS, Carlson D, Chiganer GJ, Parodi R, Greca A, Tosello ME, et al. Systemic infection caused by Trichosporon asahii in a patient with liver transplant. Med Mycol. 2008;46:719-23.
Shinde RS, Mantur BG, Patil G, Parande MV, Parande AM. Meningitis due to Rhodotorula glutinis in an HIV infected patient. Indian J Med Microbiol. 2008;26:375-7.
de Rojas M, Riazzo C, Callejón R, Guevara D, Cutillas C. Morphobiometrical and molecular study of two populations of Demodex folliculorum from humans. Parasitol Res. 2012;110:227-33.
Kligman AM, Christensen MS. Demodex folliculorum: Requirements for understanding its role in human skin disease. J Invest Dermatol. 2011;131:8-10.
Lacey N, Kavanagh K, Tseng SC. Under the lash: Demodex mites in human diseases. Biochem (Lond). 2009;31:2-6.
Meyer T, Stockfleth E, Christophers E. Immune response profiles in human skin. Br J Dermatol. 2007;157:1-7.
Schauber J, Gallo RL. Antimicrobial peptides and the skin immune defense system J Allergy Clin Immunol. 2008;122:261-6.
Chamorro CI, Weber G, Grönberg A, Pivarcsi A, Stahle M. The human antimicrobial peptide LL-37 suppresses apoptosis in keratinocytes. J Invest Dermatol. 2009;129:937-44.
Krishna S, Miller LS. Innate and adaptive immune responses against Staphylococcus aureus skin infections. Semin Immunopathol. 2012;34:261-80.
Yamasaki K, Schauber J, Coda A, Lin H, Dorschner RA, Schechter NM, et al. Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. FASEB J. 2006;20:2068-80.
Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, et al. Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1. Nature. 2011;469:419-23.
Abtin A, Eckhart L, Gläser R, Gmeiner R, Mildner M, Tschachler E, et al. The antimicrobial heterodimer S100A8/S100A9 (calprotectin) is upregulated by bacterial flagellin in human epidermal keratinocytes. J Invest Dermatol. 2010;130:2423-30.
Maerki C, Meuter S, Liebi M, Mühlemann K, Frederick MJ, Yawalkar N, et al. Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections. J Immunol. 2009;182:507-14.
Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, et al. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med. 2009;15:1377-82.
Bastos MC, Ceotto H, Coelho ML, Nascimento JS. Staphylococcal antimicrobial peptides: Relevant properties and potential biotechnological applications. Curr Pharm Biotechnol. 2009;10:38-41.
Lee DY, Yamasaki K, Rudsil J, Zouboulis CC, Park GT, Yang JM, et al. Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill Propionibacterium acnes. J Invest Dermatol. 2008;128:1863-6.
Nakatsuji T, Kao MC, Fang JY, Zouboulis CC, Zhang L, Gallo RL, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: Its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009;129:2480-8.
Del Rosso JQ, Levin J. Clinical relevance of maintaining the structural and functional integrity of the stratum corneum: Why is it important to you? J Drugs Dermatol. 2011;10:s5-12.
Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, et al. Topographical and temporal diversity of the human skin microbiome. Science. 2009;324:1190-2.
Frank DN, Feazel LM, Bessesen MT, Price CS, Janoff EN, Pace NR, et al. The human nasal microbiota and Staphylococcus aureus carriage. PLoS One. 2010;5:e10598.
Iwase T, Uehara Y, Shinji H, Tajima A, Seo H, Takada K, et al. Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization. Nature. 2010;465:346-9.
Delisle AL. Activity of two Streptococcus mutans bacteriocins in the presence of saliva, levan, and dextran. Infect Immun. 1976;13:619-26.
Joklik WK, Willett HP, Amos BD, Wilfert CM. Flora normal e infecciones oportunistas. En: Joklik WK, Willet HP, Amos BD, Wilfert CM. Zinsser Microbiología. 20ª edición. Buenos Aires: Editorial Médica Panamericana; 1994; p. 524-681.
Segata N, Haake SK, Mannon P, Lemon KP, Waldron L, Gevers D, et al. Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol. 2012;13:R42.
Lamont RF, Sobel JD, Akins RA, Hassan SS, Chaiworapongsa T, Kusanovic JP, et al. The vaginal microbiome: New information about genital tract flora using molecular based techniques. BJOG. 2011;118:533-49.
Brotman RM. Vaginal microbiome and sexually transmitted infections: An epidemiologic perspective. J Clin Invest. 2011;121:4610-7.
Randelovic G, Mladenovic V, Ristic L, Otasevic S, Brankovic S, Mladenovic-Antic S, et al. Microbiological aspects of vulvovaginitis in prepubertal girls. Eur J Pediatr. 2012;171:1203-8.
Linhares IM, Giraldo PC, Baracat EC. New findings about vaginal bacterial flora. Rev Assoc Med Bras. 2010;56:370-4.
Fierer N, Hamady M, Lauber CL, Knight R. The influence of sex, handedness, and washing on the diversity of hand surface bacteria. Proc Natl Acad Sci USA. 2008;105:17994-9.
Dao H Jr, Kazin RA. Gender differences in skin: A review of the literature. Gend Med. 2007;4:308-28.
Holland KT, Bojar RA. Cosmetics: What is their influence on the skin microflora? Am J Clin Dermatol. 2002;3:445-9.
Staudinger T, Pipal A, Redl B. Molecular analysis of the prevalent microbiota of human male and female forehead skin compared to forearm skin and the influence of make-up. J Appl Microbiol. 2011;110:1381-9.
Domínguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA. 2010;107:11971-5.
Gao Z, Tseng CH, Pei Z, Blaser MJ. Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci USA. 2007;104:2927-32.
Capone KA, Dowd SE, Stamatas GN, Nikolovski J. Diversity of the human skin microbiome early in life. J Invest Dermatol. 2011;131:2026-32.
Elias PM. The skin barrier as an innate immune element. Semin Immunopathol. 2007;29:3-14.
Choi EH, Demerjian M, Crumrine D, Brown BE, Mauro T, Elias PM, et al. Glucocorticoid blockade reverses psychological stressinduced abnormalities in epidermal structure and function. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1657-62.
Bibel DJ, Aly R, Shinefield HR. Antimicrobial activity of sphingosines. J Invest Dermatol. 1992;98:269-73.
Krishna S, Miller LS. Host-pathogen interactions between the skin and Staphylococcus aureus. Curr Opin Microbiol. 2012;15:28-35.
Zomorodian K, Mirhendi H, Tarazooie B, Zeraati H, Hallaji Z, Balighi K. Distribution of Malassezia species in patients with psoriasis and healthy individuals in Tehran, Iran. J Cutan Pathol. 2008;35:1027-31.
Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 2002;347:1151-60.
Fahlén A, Engstrand L, Baker BS, Powles A, Fry L. Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin. Arch Dermatol Res. 2012;304:15-22.
Taylor M, González M, Porter R. Pathways to inflammation: Acne pathophysiology. Eur J Dermatol. 2011;21:323-33.
Chronnell CM, Ghali LR, Ali RS, Quinn AG, Holland DB, Bull JJ, et al. Human betadefensin-1 and -2 expression in human pilosebaceous units: Upregulation in acne vulgaris lesions. J Invest Dermatol. 2001;117:1120-5.
Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, et al. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med. 2007;13:975-80.
Miller M, Cook HA, Furuya EY, Bhat M, Lee MH, Vavagiakis P, et al. Staphylococcus aureus in the community: Colonization versus infection. PLoS One. 2009;4:e6708.
Wichmann K, Uter W, Weiss J, Breuer K, Heratizadeh A, Mai U, et al. Isolation of alpha-toxin-producing Staphylococcus aureus from the skin of highly sensitized adult patients with severe atopic dermatitis. Br J Dermatol. 2009;161:300-5.
Ong PY, Leung DY. The infectious aspects of atopic dermatitis. Immunol Allergy Clin North Am. 2010;30:309-21.
Sugita T, Tajima M, Amaya M, Tsuboi R, Nishikawa A. Genotype analysis of Malassezia restricta as the major cutaneous flora in patients with atopic dermatitis and healthy subjects. Microbiol Immunol. 2004;48:755-9.
Schwartz JR, Messenger AG, Tosti A, Todd G, Hordinsky M, Hay RJ, et al. A comprehensive pathophysiology of dandruff and seborrheic dermatitis –towards a more precise definition of scalp health. Acta Derm Venereol. 2013;93:131-7