Omalizumab en dermatología

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Artículo de revisión
Rev Asoc Colomb Dermatol. 2015; 23: 1 (Enero-Marzo), 39-48

Omalizumab en dermatología

Omalizumab in Dermatology
Autor(es): 
Victoria Lucía Dávila
mmvelasquez@yahoo.com
Médica, Universidad Pontificia Bolivariana, Clínica Cardiovid, Medellín, Colombia
Margarita María Velásquez
Dermatóloga y doctora en Ciencias Básicas Biomédicas, énfasis en Inmunología; profesora, Sección de Dermatología, Centro de Investigaciones Dermatológicas CIDERM, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
Resumen: 

El omalizumab es un anticuerpo monoclonal ‘humanizado’ que se une selectivamente a IgE libre, inhibiendo su unión a los receptores, tanto el de alta afinidad (FceRI) en la superficie de mastocitos y basófilos, como el de baja afinidad (FceRII). Actualmente, se encuentra aprobado por la Food and Drug Administration (FDA) para el tratamiento del asma grave no controlada; sin embargo, existen otras enfermedades en las cuales se ha demostrado su efectividad. Condiciones dermatológicas como la urticaria crónica, la dermatitis atópica, la mastocitosis cutánea y el penfigoide ampolloso, son algunas de ellas. Esta revisión se enfoca en documentar los hallazgos sobre el uso del omalizumab en el tratamiento y control de enfermedades cutáneas.

Palabras clave: 
omalizumab, urticaria crónica, Dermatitis atopica, penfigoide ampolloso, mastocitosis cutánea.

Summary: 

Omalizumab is a monoclonal humanized antibody which selectively binds to the free IgE avoiding its binding to both the high affinity receptor (FceRI) on the surface of mast cells and basophils, and the low affinity receptor (FceRII). It is currently approved by the Food and Drug Administration (FDA) for the treatment of severe non controlled asthma. Its effectiveness has also been demonstrated in dermatological diseases, such as: chronic urticaria, atopic dermatitis, cutaneous mastocytosis and bullous pemphigoid. This review focuses on the report of the existent evidence in the literature about the effect of omalizumab in treating and controlling cutaneous diseases.

Key words: 
Omalizumab, chronic urticaria, atopic dermatitis, bullous pemphigoid, cutaneous mastocytosis.
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