Aspectos de la IL-17 en la inmunopatogénesis de la psoriasis: un nuevo blanco terapéutico

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Artículo de revisión
Immunopathogenic aspects of IL-17 in psoriasis: a novel therapeutic target

Aspectos de la IL-17 en la inmunopatogénesis de la psoriasis: un nuevo blanco terapéutico

Immunopathogenic aspects of IL-17 in psoriasis: a novel therapeutic target
Autor(es): 
Luis Carlos Ramírez
mmvelasquez@yahoo.com
Médico, residente de segundo año de Dermatología, Sección de Dermatología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Margarita María Velásquez
Médica dermatóloga, doctora en Ciencias Básicas Biomédicas con énfasis en Inmunología; profesora, Sección de Dermatología, Facultad de Medicina, Universidad de Antioquia, Centro de Investigaciones Dermatológicas, CIDERM, Medellín, Colombia.
Resumen: 

La psoriasis es una enfermedad crónica multifactorial, en la que intervienen factores ambientales, inmunológicos y genéticos. En su inmunopatogénesis participan múltiples citocinas que se han convertido en blanco terapéutico. La interleucina 17 (IL-17) es necesaria en la inmunidad contra patógenos intracelulares y extracelulares, y participa en la patogénesis de la psoriasis mediando la inflamación y el reclutamiento de diversas células del sistema inmunológico. Actualmente, se llevan a cabo estudios con medicamentos que bloquean esta citocina y su receptor, con resultados promisorios.

Palabras clave: 
IL-17, psoriasis, inmunopatogénesis, citocinas.

Summary: 

Psoriasis is a multifactorial, common disease in which environmental, immunological and genetic factors are involved. Its immunopathogenesis is mediated by multiple cytokines that have turned into a therapeutic target. IL-17 is necessary in the immunity against intracellular and extracellular pathogens, but can also contribute in the pathogenesis of psoriasis, mediating inflammation and recruiting cells. There are ongoing trials with drugs that block this cytokine and its receptor, with promising results.

Key words: 
IL-17, Psoriasis, immunopathogenesis, cytokines.
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